Synthesis and pharmacological evaluation of some new analgesic and anti-inflammatory molecules as lead compounds
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چکیده
منابع مشابه
Microwave Assisted Synthesis, Pharmacological Activities, and Molecular Docking Studies of Ethyl 2-[2-substituted-4-(thiophenyl)thiazolyl] acetates
A series of ethyl 2-[2-arylamino-4-(thiophen-2-yl)thiazol-5-yl] acetates (5a-5k) and ethyl 2-[2-(arylhydrazino)-4-(thiophen-2-yl)thiazol-5-yl] acetates (9a-9g) were synthesized and screened for their anti-inflammatory, analgesic, and antioxidant activities. In vivo test results showed that the compounds with halogen substitution (5c, 5g, 5h, 5i and 5j) at the para position on the 2-aryl amino g...
متن کاملMicrowave Assisted Synthesis, Pharmacological Activities, and Molecular Docking Studies of Ethyl 2-[2-substituted-4-(thiophenyl)thiazolyl] acetates
A series of ethyl 2-[2-arylamino-4-(thiophen-2-yl)thiazol-5-yl] acetates (5a-5k) and ethyl 2-[2-(arylhydrazino)-4-(thiophen-2-yl)thiazol-5-yl] acetates (9a-9g) were synthesized and screened for their anti-inflammatory, analgesic, and antioxidant activities. In vivo test results showed that the compounds with halogen substitution (5c, 5g, 5h, 5i and 5j) at the para position on the 2-aryl amino g...
متن کاملEvaluation of Pharmacological Activities of Leaves and Bark of Myristica fatua var. magnifica Extracts
Myristica fatua var. magnifica (Beddome) Sinclair belongs to the family Myristicaceae. It is a tree used as an important plant to cure various diseases. In the present study the Petroleum ether, Ethyl acetate and Methanolic extracts of Myristica fatua was evaluated for its toxicity, potential analgesic, depressant and in vitro and in vivo anti-inflammatory activity. The extracts at different co...
متن کاملSynthesis, Characterization and Anti-Inflammatory Activity of Some 1, 3,4 -Oxadiazole Derivatives
A series of five-membered heterocyclic rings were synthesized by the reaction between benzoyl chloride and various chlolro-nitro-benzoyl chlorides and semi carbazide to form (C1-C7) compounds and was tested for their anti-inflammatory activity determined by rat-paw-oedema method. All the synthesis compounds have been characterized by 1HNMR, IR and Mass spectral data. The compounds were purified...
متن کاملSynthesis, Characterization and Anti-Inflammatory Activity of Some 1, 3,4 -Oxadiazole Derivatives
A series of five-membered heterocyclic rings were synthesized by the reaction between benzoyl chloride and various chlolro-nitro-benzoyl chlorides and semi carbazide to form (C1-C7) compounds and was tested for their anti-inflammatory activity determined by rat-paw-oedema method. All the synthesis compounds have been characterized by 1HNMR, IR and Mass spectral data. The compounds were purified...
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تاریخ انتشار 2015